Integrating artificial intelligence and nanotechnology for precision cancer medicine
Artificial intelligence (AI) and nanotechnology are two fields that are instrumental in realizing
the goal of precision medicine—tailoring the best treatment for each cancer patient. Recent …
the goal of precision medicine—tailoring the best treatment for each cancer patient. Recent …
Extracellular vesicles as drug delivery systems: lessons from the liposome field
R van der Meel, MHAM Fens, P Vader… - Journal of controlled …, 2014 - Elsevier
Extracellular vesicles (EVs) are membrane-derived particles surrounded by a (phospho)
lipid bilayer that are released by cells in the human body. In addition to direct cell-to-cell …
lipid bilayer that are released by cells in the human body. In addition to direct cell-to-cell …
Multifunctional lipid bilayer nanocarriers for cancer immunotherapy in heterogeneous tumor microenvironments, combining immunogenic cell death stimuli with …
In addition to the contribution of cancer cells, the solid tumor microenvironment (TME) has a
critical role in determining tumor expansion, antitumor immunity, and the response to …
critical role in determining tumor expansion, antitumor immunity, and the response to …
Mechanistic understanding from molecular dynamics simulation in pharmaceutical research 1: drug delivery
In this review, we outline the growing role that molecular dynamics simulation is able to play
as a design tool in drug delivery. We cover both the pharmaceutical and computational …
as a design tool in drug delivery. We cover both the pharmaceutical and computational …
[HTML][HTML] LinTT1 peptide-functionalized liposomes for targeted breast cancer therapy
Breast cancer, with around 2 million new cases in 2019, is the second most common cancer
worldwide and the second leading cause of cancer death among females. The aim of this …
worldwide and the second leading cause of cancer death among females. The aim of this …
[PDF][PDF] Liposomal drug delivery: a versatile platform for challenging clinical applications
Liposomes are lipid based vesicular systems that offer novel platform for versatile drug
delivery to target cell. Liposomes were first reported by Bangham and his co-workers in …
delivery to target cell. Liposomes were first reported by Bangham and his co-workers in …
Computational modeling for the design and development of nano based drug delivery systems
The nanoparticle delivery system is one of the promising nanotechnology applications for
efficient drug delivery to the targeted site. However, the selection of lead excipient …
efficient drug delivery to the targeted site. However, the selection of lead excipient …
Computational modeling for formulation design
Highlights•Formulation design comprises complicated stages.•Formulation optimization
requires an exhaustive experimental work.•Computational tools help in formulation …
requires an exhaustive experimental work.•Computational tools help in formulation …
Doxorubicin hydrochloride-loaded nonionic surfactant vesicles to treat metastatic and non-metastatic breast cancer
Doxorubicin hydrochloride (DOX) is currently used to treat orthotropic and metastatic breast
cancer. Because of its side effects, the use of DOX in cancer patients is sometimes limited; …
cancer. Because of its side effects, the use of DOX in cancer patients is sometimes limited; …
Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor
Checkpoint blocking antibodies that interfere in the PD-1/PD-L1 axis provide effective
cancer immunotherapy for tumors that are immune inflamed or induced to become “hot”. It …
cancer immunotherapy for tumors that are immune inflamed or induced to become “hot”. It …