Coronavirus spike protein and tropism changes
RJG Hulswit, CAM De Haan, BJ Bosch - Advances in virus research, 2016 - Elsevier
Coronaviruses (CoVs) have a remarkable potential to change tropism. This is particularly
illustrated over the last 15 years by the emergence of two zoonotic CoVs, the severe acute …
illustrated over the last 15 years by the emergence of two zoonotic CoVs, the severe acute …
Protein dynamics and function from solution state NMR spectroscopy
M Kovermann, P Rogne, M Wolf-Watz - Quarterly reviews of …, 2016 - cambridge.org
It is well-established that dynamics are central to protein function; their importance is
implicitly acknowledged in the principles of the Monod, Wyman and Changeux model of …
implicitly acknowledged in the principles of the Monod, Wyman and Changeux model of …
Direct visualization of the conformational dynamics of single influenza hemagglutinin trimers
Influenza hemagglutinin (HA) is the canonical type I viral envelope glycoprotein and
provides a template for the membrane-fusion mechanisms of numerous viruses. The current …
provides a template for the membrane-fusion mechanisms of numerous viruses. The current …
[PDF][PDF] A review on COVID-19: origin, spread, symptoms, treatment, and prevention
A novel type of coronavirus, identified as 2019-nCoV or COVID-19, appeared in Wuhan,
China, in late 2019 and continued to spread in 2020. On January 24th, 2020, about 830 …
China, in late 2019 and continued to spread in 2020. On January 24th, 2020, about 830 …
Concerted transformation of a hyper-paused transcription complex and its reinforcing protein
RfaH, a paralog of the universally conserved NusG, binds to RNA polymerases (RNAP) and
ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical …
ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical …
Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion
E Dodero-Rojas, JN Onuchic, PC Whitford - Elife, 2021 - elifesciences.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious, and
transmission involves a series of processes that may be targeted by vaccines and …
transmission involves a series of processes that may be targeted by vaccines and …
Divide-and-conquer: machine-learning integrates mammalian and viral traits with network features to predict virus-mammal associations
Our knowledge of viral host ranges remains limited. Completing this picture by identifying
unknown hosts of known viruses is an important research aim that can help identify and …
unknown hosts of known viruses is an important research aim that can help identify and …
Dynamic asymmetry exposes 2019-nCoV prefusion spike
The novel coronavirus (2019-nCoV) spike protein is a smart molecular machine that
instigates the entry of coronavirus to the host cell causing the COVID-19 pandemic. In this …
instigates the entry of coronavirus to the host cell causing the COVID-19 pandemic. In this …
SARS-CoV fusion peptides induce membrane surface ordering and curvature
Viral membrane fusion is an orchestrated process triggered by membrane-anchored viral
fusion glycoproteins. The S2 subunit of the spike glycoprotein from severe acute respiratory …
fusion glycoproteins. The S2 subunit of the spike glycoprotein from severe acute respiratory …
Hemagglutinin-mediated membrane fusion: a biophysical perspective
S Boonstra, JS Blijleven, WH Roos… - Annual review of …, 2018 - annualreviews.org
Influenza hemagglutinin (HA) is a viral membrane protein responsible for the initial steps of
the entry of influenza virus into the host cell. It mediates binding of the virus particle to the …
the entry of influenza virus into the host cell. It mediates binding of the virus particle to the …