Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic.
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The …

Skeletal muscle is an essential tissue that attaches to bones and facilitates body
movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an …

Interleukin-6 is a pleiotropic cytokine regulating different tissues and organs in diverse and
sometimes discrepant ways. The dual and sometime hermetic nature of IL-6 action has been …

In the last decade, clear evidence has emerged that the cellular components of skeletal
muscle are important sites for the release of proteins and peptides called “myokines” …

Multinuclear muscle fibers are the most voluminous cells in skeletal muscle and the primary
drivers of growth in response to loading. Outside the muscle fiber, however, is a diversity of …

Sarcopenic obesity (SO) is a condition characterized by the occurrence of both sarcopenia
and obesity and imposes a heavy burden on the health of the elderly. Controversies and …

Hypertrophy of ligamentum flavum (LF), along with disk protrusion and facet joints
degeneration, is associated with the development of lumbar spinal canal stenosis (LSCS) …

Fibrosis is defined as the pathological progress of excessive extracellular matrix (ECM),
such as collagen, fibronectin, and elastin deposition, as the regenerative capacity of cells …

We developed a (three-dimensional) 3D scaffold, we named HY-FIB, incorporating a force-
transmission band of braided hyaluronate embedded in a cell localizing fibrin hydrogel and …

Progressive weight loss combined with skeletal muscle atrophy, termed cachexia, is a
common comorbidity associated with cancer that results in adverse consequences for the …