Cancer associated fibroblasts: the architects of stroma remodeling

A Santi, FG Kugeratski, S Zanivan - Proteomics, 2018 - Wiley Online Library
Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of
soluble factors, extracellular matrix components and extracellular vesicles. While in …

Imaging mass cytometry

Q Chang, OI Ornatsky, I Siddiqui, A Loboda… - Cytometry part …, 2017 - Wiley Online Library
Abstract Imaging Mass Cytometry (IMC) is an expansion of mass cytometry, but rather than
analyzing single cells in suspension, it uses laser ablation to generate plumes of particles …

An immune clock of human pregnancy

N Aghaeepour, EA Ganio, D Mcilwain, AS Tsai… - Science …, 2017 - science.org
The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate
that these adaptations are precisely timed, reflecting an immune clock of pregnancy in …

The use of skin models in drug development

SH Mathes, H Ruffner, U Graf-Hausner - Advanced drug delivery reviews, 2014 - Elsevier
Three dimensional (3D) tissue models of the human skin are probably the most developed
and understood in vitro engineered constructs. The motivation to accomplish organotypic …

ANPELA: Significantly Enhanced Quantification Tool for Cytometry‐Based Single‐Cell Proteomics

Y Zhang, H Sun, X Lian, J Tang, F Zhu - Advanced science, 2023 - Wiley Online Library
ANPELA is widely used for quantifying traditional bulk proteomic data. Recently, there is a
clear shift from bulk proteomics to the single‐cell ones (SCP), for which powerful cytometry …

Clinical recovery from surgery correlates with single-cell immune signatures

B Gaudillière, GK Fragiadakis, RV Bruggner… - Science translational …, 2014 - science.org
Delayed recovery from surgery causes personal suffering and substantial societal and
economic costs. Whether immune mechanisms determine recovery after surgical trauma …

High‐parameter mass cytometry evaluation of relapsed/refractory multiple myeloma patients treated with daratumumab demonstrates immune modulation as a novel …

HC Adams III, F Stevenaert, J Krejcik… - Cytometry Part …, 2019 - Wiley Online Library
Daratumumab is a CD38‐targeted human monoclonal antibody with direct anti‐myeloma
cell mechanisms of action. Flow cytometry in relapsed and/or refractory multiple myeloma …

A beginner's guide to analyzing and visualizing mass cytometry data

AK Kimball, LM Oko, BL Bullock… - The Journal of …, 2018 - journals.aai.org
Mass cytometry has revolutionized the study of cellular and phenotypic diversity, significantly
expanding the number of phenotypic and functional characteristics that can be measured at …

Multi‐dimensional organic mass cytometry: simultaneous analysis of proteins and metabolites on single cells

S Xu, M Liu, Y Bai, H Liu - Angewandte Chemie International …, 2021 - Wiley Online Library
Mass cytometry is attracting significant attention for enabling spatiotemporal high‐
throughput single‐cell analysis. As the first demonstration of the simultaneous detection of …

Identification of transcriptional regulators in the mouse immune system

V Jojic, T Shay, K Sylvia, O Zuk, X Sun, J Kang… - Nature …, 2013 - nature.com
The differentiation of hematopoietic stem cells into cells of the immune system has been
studied extensively in mammals, but the transcriptional circuitry that controls it is still only …