Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering
therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages …

Despite the decades-old knowledge that diabetes mellitus is a major risk factor for
cardiovascular disease, the reasons for this association are only partially understood. While …

Recent clinical trials in people with type 2 diabetes have demonstrated beneficial actions on
heart and kidney outcomes following treatment with GLP-1RAs. In part, these actions are …

Low-grade systemic inflammation is a key pathophysiological component of atherosclerotic
cardiovascular disease (CVD), and long-term activation of myeloid cells is thought to be …

OBJECTIVE People with type 1 diabetes are at risk for developing micro-and macrovascular
complications. Little is known about the gut microbiome in long-standing type 1 diabetes. We …

Periodontitis and diabetes are two major global health problems despite their prevalence
being significantly underreported and underestimated. Both epidemiological and …

Diabetes mellitus is a main risk factor for periodontitis, but until now, the underlying
molecular mechanisms remain unclear. Diabetes can increase the pathogenicity of the …

Obesity and obesity-related diseases like type 2 diabetes (T2D) are prominent global health
issues; therefore, there is a need to better understand the mechanisms underlying these …