[HTML][HTML] Intrathecal delivery of protein therapeutics to the brain: a critical reassessment

P Calias, WA Banks, D Begley, M Scarpa… - Pharmacology & …, 2014 - Elsevier
Disorders of the central nervous system (CNS), including stroke, neurodegenerative
diseases, and brain tumors, are the world's leading causes of disability. Delivery of drugs to …

Human body-fluid proteome: quantitative profiling and computational prediction

L Huang, D Shao, Y Wang, X Cui, Y Li… - Briefings in …, 2021 - academic.oup.com
Empowered by the advancement of high-throughput bio technologies, recent research on
body-fluid proteomes has led to the discoveries of numerous novel disease biomarkers and …

Altered choroid plexus gene expression in major depressive disorder

CA Turner, RC Thompson, WE Bunney… - Frontiers in human …, 2014 - frontiersin.org
Given the emergent interest in biomarkers for mood disorders, we assessed gene
expression in the choroid plexus (CP), the region that produces cerebrospinal fluid (CSF), in …

Specific recognition of bovine serum albumin using superparamagnetic molecularly imprinted nanomaterials prepared by two-stage core–shell sol–gel polymerization

R Gao, X Mu, J Zhang, Y Tang - Journal of Materials Chemistry B, 2014 - pubs.rsc.org
A novel type of uniform magnetic imprinted nanomaterial for the recognition of bovine serum
albumin (BSA) was prepared by anchoring MIP shells on the surface of silica deposited …

Efficient synthesis of molecularly imprinted polymers with bio‐recognition sites for the selective separation of bovine hemoglobin

Z Zhang, L Li - Journal of separation science, 2018 - Wiley Online Library
We developed a facile approach to the construction of bio‐recognition sites in silica
nanoparticles for efficient separation of bovine hemoglobin based on amino‐functionalized …

Automated mass spectrometry–based functional assay for the routine analysis of the secretome

AG Ngounou Wetie, I Sokolowska… - Journal of …, 2013 - journals.sagepub.com
The secretome represents the set of proteins secreted into the extracellular space of cells.
These proteins have been shown to play a major role in cell-cell communication. For …

Proteomic identification of novel differentiation plasma protein markers in hypobaric hypoxia-induced rat model

Y Ahmad, NK Sharma, MF Ahmad, M Sharma, I Garg… - PLoS …, 2014 - journals.plos.org
Background Hypobaric hypoxia causes complex changes in the expression of genes,
including stress related genes and corresponding proteins that are necessary to maintain …

Separation of intact proteins by using polyhedral oligomeric silsesquioxane based hybrid monolithic capillary columns

Z Liu, J Ou, Z Liu, J Liu, H Lin, F Wang, H Zou - Journal of Chromatography …, 2013 - Elsevier
High-efficient separation of intact proteins is still a huge challenge in proteome analysis of
complex biological samples by using capillary columns. In this study, four POSS-based …

Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction

KA Thibert, GV Raymond, DR Nascene, WP Miller… - PloS one, 2012 - journals.plos.org
Background X-linked adrenoleukodystrophy results from mutations in the ABCD1 gene
disrupting the metabolism of very-long-chain fatty acids. The most serious form of ALD …

Glia-based biomarkers and their functional role in the CNS

MK Jha, K Suk - Expert review of proteomics, 2013 - Taylor & Francis
Glial cells, a close partner to neurons, are able to communicate with each other and with
neurons through secreted proteins and other molecules. Secreted proteins in the …