[HTML][HTML] Butyrate ameliorates chronic alcoholic central nervous damage by suppressing microglia-mediated neuroinflammation and modulating the microbiome-gut …

H Wei, C Yu, C Zhang, Y Ren, L Guo, T Wang… - Biomedicine & …, 2023 - Elsevier
Background Alcohol abuse triggers neuroinflammation, leading to neuronal damage and
further memory and cognitive impairment. Few satisfactory advances have been made in the …

Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder

J Wei, TY Lambert, A Valada, N Patel, K Walker… - Nature …, 2023 - nature.com
Dynamic interactions of neurons and glia in the ventral midbrain mediate reward and
addiction behavior. We studied gene expression in 212,713 ventral midbrain single nuclei …

The beauty and complexity of the small heat shock proteins: a report on the proceedings of the fourth workshop on small heat shock proteins

H Ecroyd, B Bartelt-Kirbach, A Ben-Zvi… - Cell Stress and …, 2023 - Springer
Abstract The Fourth Cell Stress Society International workshop on small heat shock proteins
(sHSPs), a follow-up to successful workshops held in 2014, 2016 and 2018, took place as a …

Perspective from single‐cell sequencing: Is inflammation in acute ischemic stroke beneficial or detrimental?

X Deng, Z Hu, S Zhou, Y Wu, M Fu… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Acute ischemic stroke (AIS) is a common cerebrovascular event associated with
high incidence, disability, and poor prognosis. Studies have shown that various cell types …

Characterization of obesity-related diseases and inflammation using single cell immunophenotyping in two different diet-induced obesity models

Z Ruppert, P Neuperger, B Rákóczi, N Gémes… - International Journal of …, 2024 - nature.com
Background Obesity is a growing problem worldwide and a major risk factor for many
chronic diseases. The accumulation of adipose tissue leads to the release of significant …

Polystyrene nano-and microplastic particles induce an inflammatory gene expression profile in rat neural stem cell-derived astrocytes in vitro

KA Marcellus, S Bugiel, A Nunnikhoven, I Curran… - Nanomaterials, 2024 - mdpi.com
Microplastics are considered an emerging environmental pollutant due to their ubiquitous
presence in the environment. However, the potential impact of microplastics on human …

Transcriptomic analyses of neurotoxic astrocytes derived from adult triple transgenic Alzheimer's disease mice

D Carvalho, P Diaz-Amarilla, R Dapueto… - Journal of Molecular …, 2023 - Springer
Neurodegenerative diseases such as Alzheimer's disease have been classically studied
from a purely neuronocentric point of view. More recent evidences support the notion that …

The small heat shock protein, HSPB1, interacts with and modulates the physical structure of membranes

B Csoboz, I Gombos, Z Kóta, B Dukic… - International Journal of …, 2022 - mdpi.com
Small heat shock proteins (sHSPs) have been demonstrated to interact with lipids and
modulate the physical state of membranes across species. Through these interactions …

Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP/PS1 mice

S Kang, J Lee, DN Ali, S Choi, J Nesbitt, PH Min… - Scientific reports, 2024 - nature.com
Alcohol use disorder has been associated with the development of neurodegenerative
diseases, including Alzheimer's disease (AD). However, recent studies demonstrate that …

Distinct brain regional proteome changes in the rTg‐DI rat model of cerebral amyloid angiopathy

JM Schrader, F Xu… - Journal of …, 2021 - Wiley Online Library
Cerebral amyloid angiopathy (CAA), a prevalent cerebral small vessel disease in the elderly
and a common comorbidity of Alzheimer's disease, is characterized by cerebral vascular …