Due to its excellent physical and chemical properties and low price, plastic has replaced part
of the use of stone, wood and metal. The inability to degrade and improper handling have …

With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Recent advances in human genetics, together with a large body of epidemiologic,
preclinical, and clinical trial results, provide strong support for a causal association between …

Aims Emerging evidence suggests that remnant cholesterol (RC) promotes atherosclerotic
cardiovascular disease (ASCVD). We aimed to estimate RC-related risk beyond low-density …

The carbohydrate–insulin model of obesity posits that high-carbohydrate diets lead to
excess insulin secretion, thereby promoting fat accumulation and increasing energy intake …

Associations between per-and polyfluoroalkyl substances (PFASs) and increased blood
lipids have been repeatedly observed in humans, but a causal relation has been debated …

Abstract Background and aims This European Atherosclerosis Society (EAS) Task Force
provides practical guidance for combination therapy for elevated low-density lipoprotein …

Diabetes is now a pandemic disease. Moreover, a large number of people with prediabetes
are at risk for developing frank diabetes worldwide. Both type 1 and type 2 diabetes increase …

Aims We tested the hypothesis that high directly measured remnant cholesterol is
associated with increased risk of ischaemic heart disease (IHD) and myocardial infarction …

ATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by
generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis. Mendelian …