Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment

J Baj, A Forma, M Sitarz, P Portincasa, G Garruti… - Cells, 2020 - mdpi.com
Gastric cancer constitutes one of the most prevalent malignancies in both sexes; it is
currently the fourth major cause of cancer-related deaths worldwide. The pathogenesis of …

Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression

P Díaz, M Valenzuela Valderrama, J Bravo… - Frontiers in …, 2018 - frontiersin.org
Helicobacter pylori (H. pylori) infection is the major risk factor associated with the
development of gastric cancer. The transition from normal mucosa to non-atrophic gastritis …

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

S Ansari, Y Yamaoka - Toxins, 2019 - mdpi.com
Helicobacter pylori colonizes the gastric epithelial cells of at least half of the world's
population, and it is the strongest risk factor for developing gastric complications like chronic …

Helicobacter pylori and Its Role in Gastric Cancer

VE Reyes - Microorganisms, 2023 - mdpi.com
Gastric cancer is a challenging public health concern worldwide and remains a leading
cause of cancer-related mortality. The primary risk factor implicated in gastric cancer …

[HTML][HTML] Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis

MA Valenzuela, J Canales, AH Corvalán… - World journal of …, 2015 - ncbi.nlm.nih.gov
The sequence of events associated with the development of gastric cancer has been
described as “the gastric precancerous cascade”. This cascade is a dynamic process that …

How Helicobacter pylori senses, targets and interacts with the gastric epithelium

D Keilberg, KM Ottemann - Environmental microbiology, 2016 - Wiley Online Library
H elicobacter pylori is a human‐specific pathogen that chronically infects about 50% of the
world's population. After travelling through the harsh environment of the stomach lumen, H …

[HTML][HTML] Helicobacter pylori gamma-glutamyl transpeptidase and its pathogenic role

V Ricci, M Giannouli, M Romano… - World journal of …, 2014 - ncbi.nlm.nih.gov
Helicobacter pylori (H. pylori) gamma-glutamyl transpeptidase (GGT) is a bacterial virulence
factor that converts glutamine into glutamate and ammonia, and converts glutathione into …

The twisted survivin connection to angiogenesis

C Sanhueza, S Wehinger, J Castillo Bennett… - Molecular cancer, 2015 - Springer
Survivin, a member of the inhibitor of apoptosis family of proteins (IAPs) that controls cell
division, apoptosis, metastasis and angiogenesis, is overexpressed in essentially all human …

Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity

A Bhattacharjee, OS Sahoo, A Sarkar, S Bhattacharya… - Infection, 2024 - Springer
Purpose This study aims to comprehensively review the multifaceted factors underlying the
successful colonization and infection process of Helicobacter pylori (H. pylori), a prominent …

The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1α in Gastric Cells

M Valenzuela-Valderrama, P Cerda-Opazo, S Backert… - Cancers, 2019 - mdpi.com
Chronic Helicobacter pylori infection increases the risk of gastric cancer and induction of
hypoxia-induced factor (HIF), which is frequently associated with the development and …