Mast cell–tumor interactions: molecular mechanisms of recruitment, intratumoral communication and potential therapeutic targets for tumor growth

D Segura-Villalobos, IG Ramírez-Moreno… - Cells, 2022 - mdpi.com
Mast cells (MCs) are tissue-resident immune cells that are important players in diseases
associated with chronic inflammation such as cancer. Since MCs can infiltrate solid tumors …

Mast cells and interleukins

AG Solimando, V Desantis, D Ribatti - International Journal of Molecular …, 2022 - mdpi.com
Mast cells play a critical role in inflammatory diseases and tumor growth. The versatility of
mast cells is reflected in their ability to secrete a wide range of biologically active cytokines …

Mast cell marker gene signature: prognosis and immunotherapy response prediction in lung adenocarcinoma through integrated scRNA-seq and bulk RNA-seq

P Zhang, J Liu, S Pei, D Wu, J Xie, J Liu… - Frontiers in …, 2023 - frontiersin.org
Background Mast cells, comprising a crucial component of the tumor immune milieu,
modulate neoplastic progression by secreting an array of pro-and antitumorigenic factors …

Role of mast cells activation in the tumor immune microenvironment and immunotherapy of cancers

X Guo, M Sun, P Yang, X Meng, R Liu - European Journal of Pharmacology, 2023 - Elsevier
The mast cell is an important cellular component that plays a crucial role in the crosstalk
between innate and adaptive immune responses within the tumor microenvironment (TME) …

Interactions between macrophages and mast cells in the female reproductive system

N Lampiasi - International Journal of Molecular Sciences, 2022 - mdpi.com
Mast cells (MCs) and macrophages (Mϕs) are innate immune cells that differentiate from
early common myeloid precursors and reside in all body tissues. MCs have a unique …

Vitamin D influences the activity of mast cells in allergic manifestations and potentiates their effector functions against pathogens

Y Mehrani, S Morovati, S Tieu, N Karimi, H Javadi… - Cells, 2023 - mdpi.com
Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens.
Local activation of these cells, either directly via pathogen recognition or indirectly via …

Mast cell proteases and metastasis

D Ribatti - Pathology-Research and Practice, 2024 - Elsevier
Mast cells exert multiple roles beyond their classical role in IgE-mediated allergic reactions.
These cells secrete pro-inflammatory and anti-inflammatory agents and change from …

Large-scale bulk RNA-seq analysis defines immune evasion mechanism related to mast cell in gliomas

R Chen, W Wu, T Liu, Y Zhao, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Accumulating evidence has demonstrated that the immune cells have an emerging role in
controlling anti-tumor immune responses and tumor progression. The comprehensive role of …

HLA-G is widely expressed by mast cells in regions of organ fibrosis in the liver, lung and kidney

N Mouchet, N Vu, B Turlin, N Rioux-Leclercq… - International Journal of …, 2021 - mdpi.com
We previously demonstrated that mast cells expressing HLA-G are associated with regions
of hepatitis C virus-induced liver fibrosis. Here, we aimed to determine whether HLA-G …

Cyclic Hypoxia Induces Transcriptomic Changes in Mast Cells Leading to a Hyperresponsive Phenotype after FcεRI Cross-Linking

Mast cells (MCs) play important roles in tumor development, executing pro-or antitumoral
functions depending on tumor type and tumor microenvironment (TME) conditions. Cyclic …