A sleep-like state in Hydra unravels conserved sleep mechanisms during the evolutionary development of the central nervous system
HJ Kanaya, S Park, J Kim, J Kusumi, S Krenenou… - Science …, 2020 - science.org
Sleep behaviors are observed even in nematodes and arthropods, yet little is known about
how sleep-regulatory mechanisms have emerged during evolution. Here, we report a sleep …
how sleep-regulatory mechanisms have emerged during evolution. Here, we report a sleep …
Assessing the Metabolic Variations of Invasive and Noninvasive Unilateral Retinoblastoma Patients
K Gulati, KM Poluri, S Kaliki - ACS omega, 2024 - ACS Publications
Retinoblastoma (Rb) is a pediatric eye cancer which if diagnosed at later stages can lead to
Rb invasion into the choroid, optic nerve, sclera, or beyond, with the potential of undergoing …
Rb invasion into the choroid, optic nerve, sclera, or beyond, with the potential of undergoing …
Virtual screening of natural inhibitors targeting ornithine decarboxylase with pharmacophore scaffolding of DFMO and validation by molecular dynamics simulation …
M Sivashanmugam, S KN, UV - Journal of Biomolecular Structure …, 2019 - Taylor & Francis
Ornithine decarboxylase (ODC) is an enzyme that initiates polyamine synthesis in human.
Polyamines play key roles in cell–cell adhesion, cell motility and cell cycle regulation …
Polyamines play key roles in cell–cell adhesion, cell motility and cell cycle regulation …
Serum Metabolomics of Retinoblastoma: Assessing the Differential Serum Metabolic Signatures of Unilateral and Bilateral Patients
K Gulati, R Manukonda, M Kairamkonda, S Kaliki… - ACS …, 2023 - ACS Publications
Retinoblastoma (Rb) is the most common pediatric eye cancer. To identify the biomarkers for
early diagnosis and monitoring the progression of Rb in patients, mapping of the alterations …
early diagnosis and monitoring the progression of Rb in patients, mapping of the alterations …
A new 68Ga-labeled ornithine derivative for PET imaging of ornithine metabolism in tumors
H Wang, K Qin, D Shi, P Wu, X Hao, H Liu, J Gao, J Li… - Amino Acids, 2023 - Springer
Ornithine metabolism plays a vital role in tumorigenesis. For cancer cells, ornithine is mainly
used as a substrate for ornithine decarboxylase (ODC) for the synthesis of polyamines. The …
used as a substrate for ornithine decarboxylase (ODC) for the synthesis of polyamines. The …
Structure based design of inhibitory peptides targeting ornithine decarboxylase dimeric interface and in vitro validation in human retinoblastoma Y79 cells
S Muthukumaran, KN Sulochana… - Journal of Biomolecular …, 2021 - Taylor & Francis
Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase
(ODC) on Ornithine. Elevated levels of polyamines are manifested proliferating cancer cells …
(ODC) on Ornithine. Elevated levels of polyamines are manifested proliferating cancer cells …
Green synthesis of silver nanoparticles by Berberis vulgaris leaf extract and their effects on cell proliferation and ODC1 gene expression in MDA-MB-231 cell line
A Safipour Afshar… - Journal of Sabzevar …, 2020 - jsums.medsab.ac.ir
Introduction: Green synthesis of silver nanoparticles is a simple and low-cost method. In
addition, finding new therapeutic effects for silver nanoparticles is considered as an …
addition, finding new therapeutic effects for silver nanoparticles is considered as an …
The supramolecular organization of cancer metabolism: From macromolecular crowding to metabolic reprogramming underlying cancer metastasis and drug …
C Balcells Nadal - 2019 - diposit.ub.edu
[eng] Metastasis and drug resistance represent the two main causes of therapeutic failure in
oncology. In the present dissertation, the interplay between them has been interrogated …
oncology. In the present dissertation, the interplay between them has been interrogated …