The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

There is a large gap between the deep understanding of mechanisms driving tumour growth
and the reasons why patients ultimately die of cancer. It is now appreciated that interactions …

JNK signaling is a critical regulator of inflammation and regeneration, but how it is controlled
in specific tissue contexts remains unclear. Here we show that, in the Drosophila intestine …

Combining cyclin-dependent kinase (CDK) inhibitors with endocrine therapy improves
outcomes for patients with metastatic estrogen receptor-positive breast cancer but its value …

The c-Jun N-terminal kinase (JNK) signalling pathway is a conserved response to a wide
range of internal and external cellular stress signals. Beside the stress response, the JNK …

As members of the mitogen-activated protein kinase (MAPK) family, the c-Jun N-terminal
kinases (JNKs) regulate cell responses to a wide range of extrinsic and intrinsic insults …

Epithelial repair relies on the activation of stress signaling pathways to coordinate tissue
repair. Their deregulation is implicated in chronic wound and cancer pathologies. Using TNF …

Inflammatory response in Drosophila to sterile (axenic) injury in embryos and adults has
received some attention in recent years, and most concentrate on the events at the injury …

The spatio-temporal regulation of gene expression determines the fate and function of
various cells and tissues and, as a consequence, the correct development and functioning of …