The tumor microenvironment (TME) plays an important role in neoplastic development.
Matrix metalloproteinases (MMPs) are critically involved in tumorigenesis by modulation of …

Cancer immunotherapies, including immune checkpoint inhibitors and immune pathway–
targeted therapies, are promising clinical strategies for treating cancer. However, drug …

To assist the translation of genetic findings to disease pathobiology and therapeutics
discovery, we present an ensemble deep learning framework, termed PIONEER (Protein …

Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in
elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one …

Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

The ubiquitin-proteasome system (UPS) modulates carcinogenesis through ubiquitination of
cancer-related target proteins, leading to their degradation in the proteasome. This may …

The homologous to the E6-AP carboxyl terminus (HECT)-type E3 ubiquitin ligases are the
selective executers in the protein ubiquitination, playing a vital role in modulation of the …

E3 ubiquitin ligases, an important part of ubiquitin proteasome system, catalyze the covalent
binding of ubiquitin to target substrates, which plays a role in protein ubiquitination and …

Ubiquitination is a dynamic post-translational modification that regulates the fate of proteins
and therefore modulates a myriad of cellular functions. At the last step of this sophisticated …

Adipogenesis, that is, the formation of terminally differentiated adipocytes is intricately
regulated by transcription factors where CCAAT/enhancer binding protein alpha (C/EBPα) …