As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

Chronic inflammation is associated with a broad spectrum of neurodegenerative diseases of
aging. Included are such disorders as Alzheimer's disease (AD), Parkinson's disease (PD) …

Influenza infection increases the incidence of myocardial infarction but the reason is
unknown. Platelets mediate vascular occlusion through thrombotic functions but are also …

Biomaterials are regularly used in various types of artificial tissues and organs, such as
oxygenators, plasmapheresis equipment, hemodialysers, catheters, prostheses, stents …

There is a growing awareness that complement plays an integral role in human physiology
and disease, transcending its traditional perception as an accessory system for pathogen …

Neuroinflammation is a characteristic of pathologically affected tissue in several
neurodegenerative disorders. These changes are particularly observed in affected brain …

Blocking the terminal complement pathway with the C5 inhibitor eculizumab has
revolutionized the clinical management of several complement-mediated diseases and has …

Postmortem immunohistochemical studies have revealed a state of chronic inflammation
limited to lesioned areas of brain in Alzheimer's disease. Some key actors in this …

Within a short few years, the number of complement inhibitors that are either approved for
therapeutic application or evaluated in late‐stage clinical trials has expanded remarkably …

Therapeutic modulation of the human complement system is considered a promising
approach for treating a number of pathological conditions. Owing to its central position in the …