Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope

MK Al-Omari, M Elaarag, RM Al-Zoubi… - Journal of Enzyme …, 2023 - Taylor & Francis
Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical
research due to their exceptional oxophilicity, low toxicity, and unique structure. They are …

Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open

G Paties Montagner, S Dominici, S Piaggi, A Pompella… - Antioxidants, 2023 - mdpi.com
Boric acid (BA) is the dominant form of boron in plasma, playing a role in different
physiological mechanisms such as cell replication. Toxic effects have been reported, both …

Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies

H Turkez, ME Arslan, A Tatar, A Mardinoglu - Neurochemistry international, 2021 - Elsevier
Glioblastoma (GB) is the most common and aggressive primary malignant astrocytoma
correlated with poor patient survival. There are no curative treatments for GB, and it …

Boric acid (boron) attenuates AOM-induced colorectal cancer in rats by augmentation of apoptotic and antioxidant mechanisms

AAJ Jabbar, ZZ Alamri, MA Abdulla… - … Trace Element Research, 2024 - Springer
Boric acid (BA) is a naturally occurring weak Lewis acid containing boron, oxygen, and
hydrogen elements that can be found in water, soil, and plants. Because of its numerous …

The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways

F Kar, C Hacioğlu, S Kaçar - Environmental Toxicology, 2023 - Wiley Online Library
Glioblastoma multiform (GBM) is a malignant tumor cancer that originates from the star‐
shaped glial support tissues, namely astrocytes, and it is associated with a poor prognosis in …

Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway

E Kahraman, E Göker - Journal of Trace Elements in Medicine and Biology, 2022 - Elsevier
Background The possible anti-cancer properties of boron, a trace element for humans, have
been demonstrated in various experimental and epidemiological studies, although the …

Boric acid affects cell proliferation, apoptosis, and oxidative stress in ALL cells

B Hilal, A Eldem, T Oz, M Pehlivan, I Pirim - Biological Trace Element …, 2024 - Springer
T-cell acute lymphoblastic leukemia (T-ALL) is a type of acute lymphoblastic leukemia from
early T-cell progenitors. Interest grows in creating less toxic agents and therapies for chemo …

Prophylactic and therapeutic efficacy of boric acid on lipopolysaccharide-induced liver and kidney inflammation in rats

E Kar, F Kar, B Can, A Çakır Gündoğdu… - … Trace Element Research, 2024 - Springer
In our study, we aimed to examine possible prophylactic (P) or therapeutic (T) effects of boric
acid (BA) on lipopolysaccharide (LPS) induced liver and kidney damages. Thirty-two rats …

Toll-like receptors and nuclear factor kappa B signaling pathway involvement in hepatorenal oxidative damage induced by some food preservatives in rats

YM Abd-Elhakim, A Behairy, MMM Hashem… - Scientific Reports, 2023 - nature.com
Chemical food preservatives are extensively found in various processed food products in the
human environment. Hence, this study aimed to investigate the effect of long-term exposure …

Boric acid alters the expression of DNA double break repair genes in MCF-7-derived breast cancer stem cells

TS Sevimli, A Ghorbani, F Gakhiyeva… - … Trace Element Research, 2024 - Springer
Breast cancer pathology ranks second in mortality among women worldwide due to the
resistance of cancer stem cells in tumor tissue to radiotherapy and chemotherapy and their …