Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

Heart failure causes significant morbidity and mortality worldwide. The understanding of
heart failure pathomechanisms and options for treatment remain incomplete. Zebrafish has …

Glyphosate, the most widely used herbicide, presents new hazards to human health. The
developmental toxicity of glyphosate, especially its cardiovascular toxicity, needs to be …

GTPBP3 is a highly conserved tRNA modifying enzyme for the biosynthesis of τm5U at the
wobble position of mitochondrial tRNAGlu, tRNAGln, tRNALys, tRNATrp and tRNALeu …

Heart failure is a global health burden responsible for high morbidity and mortality with a
prevalence of greater than 60 million individuals worldwide. One of the major causes of …

Abstract Myosin heavy chain 7 (MYH7) is a major causative gene for hypertrophic
cardiomyopathy, but the affected signaling pathways and therapeutics remain elusive. In this …

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. The major AF
susceptibility locus 4q25 establishes long-range interactions with the promoter of PITX2, a …

Cardiomyopathies are a highly heterogeneous group of heart muscle disorders. More than
100 causative genes have been linked to various cardiomyopathies, which explain about …

Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but
exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death …

Lipid metabolism dysfunction is related to clinical disorders including obesity, cancer, liver
steatosis, and cardiomyopathy. Impaired lipolytic enzymes result in altered release of free …