Molecular testing is becoming an important part of the diagnosis of any patient with cancer.
The challenge to laboratories is to meet this need, using reliable methods and processes to …

Epigenetic alterations are associated with normal biological processes such as aging or
differentiation. Changes in global epigenetic signatures, together with genetic alterations …

Direct detection methods for Treponema pallidum include dark-field microscopy (DFM),
direct fluorescence antibody (DFA) testing, immunohistochemistry (IHC), and nucleic acid …

DNA methylation analyses usually require a preceding bisulfite conversion of the DNA. The
choice of an appropriate kit for a specific application should be based on the specific …

Background Targeted Next Generation Sequencing (NGS) offers a way to implement testing
of multiple genetic aberrations in diagnostic pathology practice, which is necessary for …

Cancer biomarker studies often require nucleic acid extraction from limited amounts of
formalin-fixed, paraffin-embedded (FFPE) tissues, such as histologic sections or needle …

Background The rapid development of programmed death 1 (PD-1)/programmed death
ligand 1 (PD-L1) inhibitors has generated an urgent need for biomarkers assisting the …

Paracoccidioidomycosis (PCM) is a mycotic disease caused by the Paracoccidioides
species, a group of thermally dimorphic fungi that grow in mycelial form at 25° C and as …

BACKGROUND The analytically sensitive detection of KIT D816V in blood and bone marrow
is important for diagnosing systemic mastocytosis (SM). Additionally, precise quantification …

Balamuthia mandrillaris infection is a rare and fatal disease. We have recorded 28 cases of
Balamuthia mandrillaris infection during the past 20 years. Eighteen patients (64%) were …