The introduction of antimicrobial drugs in medicine gave hope for a future in which all
infectious diseases could be controlled. Decades later it appears certain this will not be the …

Host redox dependent physiological responses play crucial roles in the determination of
mycobacterial infection process. Mtb explores oxygen rich lung microenvironments to initiate …

Despite the great efficacy of isoniazid (INH) and rifampicin (RIF) combination, in the
treatment of tuberculosis, hepatotoxicity is the most common serious complication. The …

Biological functions of antibiotics are not limited to killing. The most likely function of
antibiotics in natural microbial ecosystems is signaling. Does this signaling function of …

Non-alcoholic fatty liver disease (NAFLD) is a prevalent disease, which features an
abnormal accumulation of lipids inside hepatocytes. Steatohepatitis plays a critical role in …

Toll-like receptors (TLRs) play an important role in mycobacterial infection, although little is
known about the roles of these receptors, cytokines and nitric oxide during anti-tuberculosis …

Abstract Background The ability of Chrysin (CHY) to scavenge free radicals has been widely
explored. The scope of the research was to show that CHY protects the rat liver against …

Rifampin, a potent antibacterial agent, is one of the main drugs used in the treatment of
mycobacterial infections. Hepatotoxicity is a well-documented adverse event. The aim of this …

Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. Nowadays
metformin is also use for efficacy in diabetes mellitus-tuberculosis coinfection patients …

Tuberculosis (TB), a chronic infectious disease, is a major cause of morbidity and mortality
worldwide. Expression of iNOS and consequent production of NO during the inflammatory …