Inflammation and tumor progression: signaling pathways and targeted intervention
H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …
either promotes or suppresses tumor progression, potentially displaying opposing effects on …
CSF-1 receptor signaling in myeloid cells
ER Stanley, V Chitu - Cold Spring Harbor perspectives …, 2014 - cshperspectives.cshlp.org
The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-
stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in …
stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in …
[PDF][PDF] A proteogenomic portrait of lung squamous cell carcinoma
Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …
Overcoming immune evasion in melanoma
Melanoma is the most aggressive and dangerous form of skin cancer that develops from
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …
transformed melanocytes. It is crucial to identify melanoma at its early stages, in situ, as it is …
Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeleton
P Rougerie, V Miskolci, D Cox - Immunological reviews, 2013 - Wiley Online Library
Macrophages are best known for their protective search and destroy functions against
invading microorganisms. These processes are commonly known as chemotaxis and …
invading microorganisms. These processes are commonly known as chemotaxis and …
The role of inflammatory cytokines and tumor associated macrophages (TAMs) in microenvironment of pancreatic cancer
Pancreatic cancer is considered as one of the most lethal types of cancer due to its poor
prognosis and lack of effective therapeutic approaches. Although many studies have been …
prognosis and lack of effective therapeutic approaches. Although many studies have been …
Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21
Macrophage polarization between the M2 (repair, protumorigenic) and M1 (inflammatory)
phenotypes is seen as a continuum of states. The detailed transcriptional events and signals …
phenotypes is seen as a continuum of states. The detailed transcriptional events and signals …
Constitutive and stimulated macropinocytosis in macrophages: roles in immunity and in the pathogenesis of atherosclerosis
SA Doodnauth, S Grinstein… - … Transactions of the …, 2019 - royalsocietypublishing.org
Macrophages respond to several stimuli by forming florid membrane ruffles that lead to fluid
uptake by macropinocytosis. This type of induced macropinocytosis, executed by a variety of …
uptake by macropinocytosis. This type of induced macropinocytosis, executed by a variety of …
[HTML][HTML] Chronic lymphocytic leukemia cells are active participants in microenvironmental cross-talk
MHA van Attekum, E Eldering, AP Kater - haematologica, 2017 - ncbi.nlm.nih.gov
The importance of the tumor microenvironment in chronic lymphocytic leukemia is widely
accepted. Nevertheless, the understanding of the complex interplay between the various …
accepted. Nevertheless, the understanding of the complex interplay between the various …
[HTML][HTML] Targeting tumor-associated macrophages to combat pancreatic cancer
The tumor microenvironment is replete with cells that evolve with and provide support to
tumor cells during the transition to malignancy. The hijacking of the immune system in the …
tumor cells during the transition to malignancy. The hijacking of the immune system in the …