Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

Bone biomaterials play a vital role in bone repair by providing the necessary substrate for
cell adhesion, proliferation, and differentiation and by modulating cell activity and function. In …

Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic
development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is …

The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

Due to their high specific surface area, graphene oxide and graphene oxide-base
nanoparticles have great potential both in dual-drug delivery and combination …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly
activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH …

Liver disease remains a leading cause of mortality worldwide despite recent successes in
the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling …

Background: The primary cilium is a singular cellular structure that extends from the surface
of many cell types and plays crucial roles in vertebrate development, including that of the …

The primary cilium is a nonmotile microtubule-based organelle in most vertebrate cell types.
The primary cilium plays a critical role in tissue development and homeostasis by sensing …