Combination of light and Ru (II) polypyridyl complexes: Recent advances in the development of new anticancer drugs

L Conti, E Macedi, C Giorgi, B Valtancoli… - Coordination Chemistry …, 2022 - Elsevier
The increasing impact of cancer on worldwide mortality makes the research of novel
chemotherapeutic agents a current and challenging issue. In the recent years, transition …

Ruthenium-based antitumor drugs and delivery systems from monotherapy to combination therapy

Y Lu, D Zhu, Q Le, Y Wang, W Wang - Nanoscale, 2022 - pubs.rsc.org
Ruthenium complex is an important compound group for antitumor drug research and
development. NAMI-A, KP1019, TLD1433 and other ruthenium complexes have entered …

Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds

ET Papish, OE Oladipupo - Current opinion in chemical biology, 2022 - Elsevier
This review focuses on light-activated ruthenium anticancer compounds and the factors that
influence which pathway is favored. Photodynamic therapy (PDT) is favored by π expansion …

Phototoxicity of Tridentate Ru (II) Polypyridyl Complex with Expanded Bite Angles toward Mammalian Cells and Multicellular Tumor Spheroids

RC Curley, CS Burke, KS Gkika, S Noorani… - Inorganic …, 2023 - ACS Publications
Tridentate ligand-coordinated ruthenium (II) polypyridyl complexes with large N–Ru–N bite
angles have been shown to promote ligand field splitting and reduce singlet–triplet state …

Ruthenium complexes with protic ligands: Influence of the position of oh groups and π expansion on luminescence and photocytotoxicity

OE Oladipupo, MC Prescott, ER Blevins… - International Journal of …, 2023 - mdpi.com
Protic ruthenium complexes using the dihydroxybipyridine (dhbp) ligand combined with a
spectator ligand (N, N= bpy, phen, dop, Bphen) have been studied for their potential activity …

Singlet Oxygen Formation vs Photodissociation for Light-Responsive Protic Ruthenium Anticancer Compounds: The Oxygenated Substituent Determines Which …

F Qu, RW Lamb, CG Cameron, S Park… - Inorganic …, 2021 - ACS Publications
Ruthenium complexes bearing protic diimine ligands are cytotoxic to certain cancer cells
upon irradiation with blue light. Previously reported complexes of the type [(N, N) 2Ru (6, 6 …

Ruthenium pincer complexes for light activated toxicity: Lipophilic groups enhance toxicity

Y Sun, S Das, SR Brown, ER Blevins, F Qu… - Journal of inorganic …, 2023 - Elsevier
Nine ruthenium CNC pincer complexes (1–9) were tested for anticancer activity in cell
culture under both dark and light conditions. These complexes included varied CNC pincer …

Synthesis and photobiological evaluation of Ru (II) complexes with expanded chelate polypyridyl ligands

RT Ryan, AC Hachey, K Stevens, SR Parkin… - Journal of Inorganic …, 2023 - Elsevier
Photoreactive Ru (II) complexes capable of ejecting ligands have been used extensively for
photocaging applications and for the creation of “photocisplatin” reagents. The incorporation …

Development of novel GnRH and Tat 48–60 based luminescent probes with enhanced cellular uptake and bioimaging profile

A Kougioumtzi, MV Chatziathanasiadou… - Dalton …, 2021 - pubs.rsc.org
There is a clear need to develop photostable chromophores for bioimaging with respect to
the classically utilized green fluorescent dye fluorescein. Along these lines, we utilized a …

Light‐responsive and Protic Ruthenium Compounds Bearing Bathophenanthroline and Dihydroxybipyridine Ligands Achieve Nanomolar Toxicity towards Breast …

OE Oladipupo, SR Brown, RW Lamb… - Photochemistry and …, 2022 - Wiley Online Library
We report new ruthenium complexes bearing the lipophilic bathophenanthroline (BPhen)
ligand and dihydroxybipyridine (dhbp) ligands which differ in the placement of the OH …