Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …

The current pandemic caused by the COVID-19 disease has reached everywhere in the
world and has affected every aspect of our lives. As of the current data, the World Health …

SARS-CoV-2 evolves rapidly in part because of its high mutation rate. Here, we examine
whether this mutational process itself has changed during viral evolution. To do this, we …

Newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global pandemic with astonishing mortality and morbidity. The high replication and …

Here, we report the synthesis, structure–activity relationship studies, enzyme inhibition,
antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate …

Ensitrelvir is a novel selective inhibitor of the 3C-like protease of SARS-CoV-2, which is
essential for viral replication. This phase 1 study of ensitrelvir assessed its safety, tolerability …

The global pandemic of coronavirus disease is still widely spread across the world causing
catastrophic effect in both human life and global economy. By the end of year 2021, it has …

Suppression of type I interferon (IFN) response is one pathological outcome of the infection
of highly pathogenic human coronaviruses. To effect this, severe acute respiratory syndrome …

The main protease (Mpro) of SARS-CoV-2 is essential for viral replication and has been the
focus of many drug discovery efforts since the start of the COVID-19 pandemic. Nirmatrelvir …

There is an urgent need for improved therapy to better control the ongoing COVID-19
pandemic. The main protease Mpro plays a pivotal role in SARS-CoV-2 replications, thereby …