Wound healing (WH) and the role fibroblasts play in the process, as well as healing
impairment and fibroblast dysfunction, have been thoroughly reviewed by other authors. We …

Macrophages and endothelial cells (ECs) have essential roles in physiological and
pathological conditions by regulating inflammation, vascularization and tissue remodelling …

Extracellular matrix (ECM)-mimicking biomaterials are considered effective tissue-
engineered scaffolds for regenerative medicine because of their biocompatibility …

Wound healing is a dynamic process which involves stages of hemostasis, inflammation,
proliferation and remodeling. Any error in this process results in abnormal wound healing …

Collagen alignment is one of the key microarchitectural signatures of many pathological
conditions, including scarring and fibrosis. Investigating how collagen alignment modulates …

The understanding of macrophages and their pathophysiological role has dramatically
changed within the last decades. Macrophages represent a very interesting cell type with …

Abstract Background Peripheral nerve injuries (PNIs) remain one of the great clinical
challenges because of their considerable long-term disability potential. Postnatal neural …

Microgravity accelerates the aging of various physiological systems, and it is well
acknowledged that aged individuals and astronauts both have increased susceptibility to …

Intracerebral hemorrhage (ICH) is one of the most dangerous types of strokes with a high
morbidity and mortality rate. Currently, the treatment of ICH is not well developed, mainly …

Background Despite the inherent regenerative ability of bone, large bone defect
regeneration remains a major clinical challenge for orthopedic surgery. Therapeutic …