During almost 40 years of use, the micronucleus assay (MN) has become one of the most
popular methods to assess genotoxicity of different chemical and physical factors, including …

Preserving the integrity of the DNA double helix is crucial for the maintenance of genomic
stability. Therefore, DNA double‐strand breaks represent a serious threat to cells. In this …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic
rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer …

Chromothripsis is a recently identified mutational phenomenon, by which a presumably
single catastrophic event generates extensive genomic rearrangements of one or a few …

Breast and ovarian cancers are the second and fifth leading causes of cancer deaths among
women. Both breast and ovarian cancers are highly heterogeneous and are presented with …

Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is
caused by chromosome segregation errors during cell divisions. Evidence is mounting that …

Chromosomal rearrangements are generally thought to accumulate gradually over many
generations. However, DNA sequencing of cancer and congenital disorders uncovered a …

The most common pediatric malignancy is acute lymphoblastic leukemia (ALL), of which T‐
cell ALL (T‐ALL) comprises 10–15% of cases. T‐ALL arises in the thymus from an immature …

Introduction Malignant pleural mesothelioma is a disease primarily associated with
exposure to the carcinogen asbestos. Whereas other carcinogen-related tumors are …