Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically
associated with other chronic inflammation-driven disorders, including cardio-metabolic …

Immune tolerance is necessary to prevent the immune system from reacting against self, and
thus to avoid the development of autoimmune diseases. In this review, we discuss key …

CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-
mediated tumor rejection, but the underlying mechanisms are incompletely understood …

Although much progress has been made in the understanding of the ontogeny and function
of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and …

Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses.
Accordingly, recent evidence from clinical studies and experimental models implicates DCs …

Glioblastomas (GBM) are the most frequent and aggressive malignant primary brain tumor
and remains a therapeutic challenge: even after multimodal therapy, median survival of …

The mammalian immune system discriminates between modes of cell death; necrosis often
results in inflammation and adaptive immunity, whereas apoptosis tends to be anti …

Cardiovascular disease is the leading cause of mortality worldwide, and atherosclerosis the
principal factor underlying cardiovascular events. Atherosclerosis is a chronic inflammatory …

Lack of immunological tolerance against self-antigens results in autoimmune disorders.
During onset of autoimmunity, dendritic cells (DCs) are thought to be critical for priming of …

High temperatures and low oxygen in aquatic environments, such as intensive aquaculture
or in natural watersheds, inevitably cause stress in fish. Fish are exposed to high …