Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …

Vital osteocytes have been well known to function as an important orchestrator in the
preservation of robustness and fidelity of the bone remodeling process. Nevertheless, some …

It is well established that alterations in phosphate metabolism have a profound effect on
hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the …

Poor bone quality contributes to bone fragility in diabetes, aging, and osteogenesis
imperfecta. However, the mechanisms controlling bone quality are not well understood …

Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …

Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly
associated with subchondral bone sclerosis. However, the cellular mechanisms responsible …

Osteocytes are master regulators of the skeleton. We mapped the transcriptome of
osteocytes from different skeletal sites, across age and sexes in mice to reveal genes and …

Abstract Purpose of Review SARS-CoV-2 drove the catastrophic global phenomenon of the
COVID-19 pandemic resulting in a multitude of systemic health issues, including bone loss …

Despite the continued development of specialized immunosuppressive therapies in the form
of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of …