Recent advances in the total synthesis of the tetrahydroisoquinoline alkaloids (2002–2020)
The tetrahydroisoquinoline (THIQ) natural products constitute one of the largest families of
alkaloids and exhibit a wide range of structural diversity and biological activity. Ranging from …
alkaloids and exhibit a wide range of structural diversity and biological activity. Ranging from …
Metabolic engineering of Escherichia coli for natural product biosynthesis
Natural products are widely employed in our daily lives as food additives, pharmaceuticals,
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …
A microbial biomanufacturing platform for natural and semisynthetic opioids
Opiates and related molecules are medically essential, but their production via field
cultivation of opium poppy Papaver somniferum leads to supply inefficiencies and insecurity …
cultivation of opium poppy Papaver somniferum leads to supply inefficiencies and insecurity …
Tyrosine biosynthesis, metabolism, and catabolism in plants
CA Schenck, HA Maeda - Phytochemistry, 2018 - Elsevier
L-Tyrosine (Tyr) is an aromatic amino acid (AAA) required for protein synthesis in all
organisms, but synthesized de novo only in plants and microorganisms. In plants, Tyr also …
organisms, but synthesized de novo only in plants and microorganisms. In plants, Tyr also …
Building microbial factories for the production of aromatic amino acid pathway derivatives: from commodity chemicals to plant-sourced natural products
The aromatic amino acid biosynthesis pathway, together with its downstream branches,
represents one of the most commercially valuable biosynthetic pathways, producing a …
represents one of the most commercially valuable biosynthetic pathways, producing a …
Rhodium-catalyzed C–H alkenylation/electrocyclization cascade provides dihydropyridines that serve as versatile intermediates to diverse nitrogen heterocycles
S Dongbang, DN Confair, JA Ellman - Accounts of chemical …, 2021 - ACS Publications
Conspectus Nitrogen heterocycles are present in approximately 60% of drugs, with
nonplanar heterocycles incorporating stereogenic centers being of considerable interest to …
nonplanar heterocycles incorporating stereogenic centers being of considerable interest to …
The chemical history of morphine: an 8000-year journey, from resin to de-novo synthesis
Evidence of human use of opium dates back as far as the sixth millennium BCE. Ancient
societies through the Renaissance period created a variety of opium products, proliferating …
societies through the Renaissance period created a variety of opium products, proliferating …
Metabolic engineering of microorganisms for the production of natural compounds
Natural products have been attracting much interest around the world for their diverse
applications, especially in drug and food industries. Plants have been a major source of …
applications, especially in drug and food industries. Plants have been a major source of …
Morphine alkaloids: History, biology, and synthesis
C Wicks, T Hudlicky, U Rinner - The Alkaloids: Chemistry and Biology, 2021 - Elsevier
This chapter provides a short overview of the history of morphine since it's isolation by
Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal …
Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal …
Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy
M Dastmalchi, X Chen, JM Hagel, L Chang… - Nature chemical …, 2019 - nature.com
The isomerization of neopinone to codeinone is a critical step in the biosynthesis of opiate
alkaloids in opium poppy. Previously assumed to be spontaneous, the process is in fact …
alkaloids in opium poppy. Previously assumed to be spontaneous, the process is in fact …