Introduction: Precision medicine is the concept of treating diseases based on environmental
factors, lifestyles, and molecular profiles of patients. This approach has been found to …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder,
caused by the degeneration of upper and lower motor neurons for which there is no truly …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly
understood clinical heterogeneity, underscored by significant differences in patient age at …

Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic
heterogeneity. Machine learning approaches have previously been utilised for patient …

Molecular and clinical heterogeneity is increasingly recognized as a common characteristic
of neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease …

Edaravone is a free-radical scavenger drug that was recently approved for the treatment of
amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. A pathological hallmark …

Amyotrophic lateral sclerosis (ALS) is a debilitating motor neuron disease and lacks effective
disease-modifying treatments. This study utilizes a comprehensive multiomic approach to …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and the most common
motor neuron disease. ALS shows substantial clinical and molecular heterogeneity. In vitro …

Splicing is a tightly orchestrated process by which the brain produces protein diversity over
time and space. While this process specializes and diversifies neurons, its deregulation may …

Background Heterozygous loss of X-linked genes like CASK and MeCP2 (Rett syndrome)
causes developmental delay in girls, while in boys, loss of the only allele of these genes …