Consequences of epigenetic derepression in facioscapulohumeral muscular dystrophy
A Greco, R Goossens, B Van Engelen… - Clinical …, 2020 - Wiley Online Library
Facioscapulohumeral muscular dystrophy (FSHD), a common hereditary myopathy, is
caused either by the contraction of the D4Z4 macrosatellite repeat at the distal end of …
caused either by the contraction of the D4Z4 macrosatellite repeat at the distal end of …
Influence of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Possible Treatments
Facioscapulohumeral muscular dystrophy (FSHD) represents the third most common form of
muscular dystrophy and is characterized by muscle weakness and atrophy. FSHD is caused …
muscular dystrophy and is characterized by muscle weakness and atrophy. FSHD is caused …
Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy
NY Saad, M Al-Kharsan, SE Garwick-Coppens… - Nature …, 2021 - nature.com
Facioscapulohumeral muscular dystrophy (FSHD) is a potentially devastating myopathy
caused by de-repression of the DUX4 gene in skeletal muscles. Effective therapies will likely …
caused by de-repression of the DUX4 gene in skeletal muscles. Effective therapies will likely …
Dynamic transcriptomic analysis reveals suppression of PGC1 α/ERR α drives perturbed myogenesis in facioscapulohumeral muscular dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) is a prevalent, incurable myopathy, linked
to epigenetic derepression of D4Z4 repeats on chromosome 4q, leading to ectopic DUX4 …
to epigenetic derepression of D4Z4 repeats on chromosome 4q, leading to ectopic DUX4 …
Antagonism between DUX4 and DUX4c highlights a pathomechanism operating through β-catenin in facioscapulohumeral muscular dystrophy
M Ganassi, N Figeac, M Reynaud… - Frontiers in cell and …, 2022 - frontiersin.org
Aberrant expression of the transcription factor DUX4 from D4Z4 macrosatellite repeats on
chromosome 4q35, and its transcriptome, associate with pathogenesis in …
chromosome 4q35, and its transcriptome, associate with pathogenesis in …
Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression
Loss of silencing of the DUX4 gene on chromosome 4 causes facioscapulohumeral
muscular dystrophy. While high level DUX4 expression induces apoptosis, the effects of low …
muscular dystrophy. While high level DUX4 expression induces apoptosis, the effects of low …
ANT1 overexpression models: Some similarities with facioscapulohumeral muscular dystrophy
S Arbogast, H Kotzur, C Frank, N Compagnone, T Sutra… - Redox Biology, 2022 - Elsevier
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disorder
characterized by progressive muscle weakness. Adenine nucleotide translocator 1 (ANT1) …
characterized by progressive muscle weakness. Adenine nucleotide translocator 1 (ANT1) …
Identification of the hyaluronic acid pathway as a therapeutic target for facioscapulohumeral muscular dystrophy
AM DeSimone, J Leszyk, KR Wagner… - Science …, 2019 - science.org
Facioscapulohumeral muscular dystrophy (FSHD) is linked to epigenetic derepression of the
germline/embryonic transcription factor DUX4 in skeletal muscle. However, the etiology of …
germline/embryonic transcription factor DUX4 in skeletal muscle. However, the etiology of …
[HTML][HTML] Systemic delivery of a DUX4-targeting antisense oligonucleotide to treat facioscapulohumeral muscular dystrophy
LF Bouwman, B den Hamer, A van den Heuvel… - … Therapy-Nucleic Acids, 2021 - cell.com
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent skeletal
muscle dystrophies. Skeletal muscle pathology in individuals with FSHD is caused by …
muscle dystrophies. Skeletal muscle pathology in individuals with FSHD is caused by …
Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes
E Takematsu, A Spencer, J Auster, PC Chen… - PLoS …, 2020 - journals.plos.org
Non-healing chronic ulcers are a serious complication of diabetes and are a major
healthcare problem. While a host of treatments have been explored to heal or prevent these …
healthcare problem. While a host of treatments have been explored to heal or prevent these …