Substance P is a peptide mainly secreted by neurons and is involved in many biological
processes, including nociception and inflammation. Animal models have provided insights …

For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …

The discovery in 1987/1988 and 1990 of the cell surface receptor KIT and its ligand, stem
cell factor (SCF), was a critical achievement in efforts to understand the development and …

Mast cells (MC s) are innate immune cells that are scattered in tissues throughout the
organism being particularly abundant at sites exposed to the environment such as the skin …

Interstitial cystitis/bladder pain syndrome is a debilitating condition of unknown etiology
characterized by persistent pelvic pain with lower urinary tract symptoms and comprises a …

It is well recognized that neuroinflammation is involved in the pathogenesis of various
neurodegenerative diseases. Microglia and astrocytes are major pathogenic components …

The versatile role of mast cells in allergy, in innate immune responses and in the regulation
of tissue homeostasis is well recognized. However, it is often not made clear that most mast …

During neuronal‐induced inflammation, mast cells may respond to stimuli such as
neuropeptides in an FcεRI‐independent manner. In this study, we characterized human …

Mast cells are not only necessary for allergic reactions, but recent findings indicate that they
are also involved in a variety of neuroinflammatory diseases, especially those worsened by …

Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but
also play a fundamental role in innate and adaptive immune responses to microbial …