FAK in cancer: from mechanisms to therapeutic strategies

HH Chuang, YY Zhen, YC Tsai, CH Chuang… - International journal of …, 2022 - mdpi.com
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

FAK in cancer: mechanistic findings and clinical applications

FJ Sulzmaier, C Jean, DD Schlaepfer - Nature reviews cancer, 2014 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Functional and clinical characteristics of focal adhesion kinases in cancer progression

Z Zhang, J Li, S Jiao, G Han, J Zhu… - Frontiers in Cell and …, 2022 - frontiersin.org
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …

Endogenous control mechanisms of FAK and PYK2 and their relevance to cancer development

R Naser, A Aldehaiman, E Díaz-Galicia, ST Arold - Cancers, 2018 - mdpi.com
Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2),
are key regulators of aggressive spreading and metastasis of cancer cells. While targeted …

ETV transcriptional upregulation is more reliable than RNA sequencing algorithms and FISH in diagnosing round cell sarcomas with CIC gene rearrangements

YC Kao, YS Sung, CL Chen, L Zhang… - Genes …, 2017 - Wiley Online Library
CIC rearrangements have been reported in two‐thirds of EWSR1‐negative small blue round
cell tumors (SBRCTs). However, a number of SBRCTs remain unclassified despite …

Sp1-mediated transcriptional regulation of MALAT1 plays a critical role in tumor

S Li, Q Wang, Q Qiang, H Shan, M Shi, B Chen… - Journal of cancer …, 2015 - Springer
Background MALAT1 was discovered as a prognostic marker for lung cancer metastasis and
has been found upregulated in many types of tumor, but its transcriptional regulation …

Neuropilin‐2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK–MAPK–ETV4–MMP–E‐cadherin deregulation

TM Fung, KY Ng, M Tong, JN Chen… - The Journal of …, 2016 - Wiley Online Library
Oesophageal squamous cell carcinoma (ESCC) is the most common histological subtype of
oesophageal cancer. The disease is particularly prevalent in southern China. The incidence …

[HTML][HTML] FAK regulates E-cadherin expression via p-SrcY416/p-ERK1/2/p-Stat3Y705 and PPARγ/miR-125b/Stat3 signaling pathway in B16F10 melanoma cells

G Pei, Y Lan, D Chen, L Ji, Z Hua - Oncotarget, 2017 - ncbi.nlm.nih.gov
Focal adhesion kinase (FAK) is involved in tumor cell migration and metastasis. However,
the underlying mechanism remains unclear. Here, we present a signaling pathway involved …

Focal adhesion kinase in ovarian cancer: a potential therapeutic target for platinum and taxane-resistant tumors

A Levy, K Alhazzani, P Dondapati… - Current Cancer Drug …, 2019 - ingentaconnect.com
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase, which is an essential player
in regulating cell migration, invasion, adhesion, proliferation, and survival. Its …

[HTML][HTML] Integration of zebrafish fin regeneration genes with expression data of human tumors in silico uncovers potential novel melanoma markers

M Hagedorn, G Siegfried, KB Hooks, AM Khatib - Oncotarget, 2016 - ncbi.nlm.nih.gov
Tissue regeneration requires expression of a large, unknown number of genes to initiate
and maintain cellular processes such as proliferation, extracellular matrix synthesis …