Cancer is a leading cause of morbidity and mortality worldwide and the ratio of incidence is
increasing. Mortality usually results from recurrence or metastases. Surgical removal of the …

In patients with cancer, opioids are principally used for the management of acute surgical
and chronic cancer‐related pain. However, opioids have many non‐analgesic effects …

Abstract EDITOR'S PERSPECTIVE What We Know about This Topic IV anesthesia may
impair anticancer immunity less than volatile anesthesia and therefore reduce recurrence …

The use of psychostimulants and alcohol disrupts blood-brain barrier (BBB) integrity,
resulting in alterations to cellular function, and contributes to neurotoxicity. The BBB is the …

IMMUNE PATHOGENESIS The principal line of defense against cancer cell invasion and
metastasis is established via the host's innate and adaptive immune response. The key …

Background Recent epidemiologic studies suggesting that there were differences in cancer
recurrence contingent on anesthetic regimens have raised the possibility that μ-opioid …

THERE has been increasing interest in the role of anes-thetic drugs and opioids in cancer
recurrence and metastasis. Epidemiologic studies in this area have suggested that patients …

This study aimed to investigate the risk of death, development of cancer, and hospital
inpatient admissions resulting from injuries and toxicity/poisoning among opioid users with …

BACKGROUND Opioids may alter immune function, thereby potentially affecting cancer
recurrence. The authors investigated the association between postdiagnosis opioid use and …

To explain a bimodal pattern of hazard of relapse among early stage breast cancer patients
identified in multiple databases, we proposed that late relapses result from steady stochastic …