Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

Muscle tissue may be damaged following intense prolonged training as a consequence of
both metabolic and mechanical factors. Serum levels of skeletal muscle enzymes or proteins …

Plasma membrane rupture (PMR) in dying cells undergoing pyroptosis or apoptosis requires
the cell-surface protein NINJ1. PMR releases pro-inflammatory cytoplasmic molecules …

Ginger has been proposed as quite a promising candidate for cancer prevention. The
purpose of this study was to assess the chemo-preventive effects of ginger. Furthermore, this …

Background It has been well documented that alcohol and its metabolites induce injury and
inflammation in the liver. However, there is no potential biomarker to monitor the extent of …

Drug-induced liver injury is a frequent side effect of many drugs, constitutes a significant
threat to patient health and has an enormous economic impact on health care expenditures …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Background Sepsis-induced organ failure is the major cause of death in critical care units,
and is characterized by a massive dysregulated inflammatory response and oxidative stress …

Liver plays a central role in the metabolism and excretion of xenobiotics which makes it
highly susceptible to their adverse and toxic effects. Liver injury caused by various toxic …

Drug-induced liver injury (DILI) is a major clinical issue associated with the majority of
commercial drugs. During DILI, the peroxynitrite (ONOO–) level is upregulated in the liver …