Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

Hematopoietic cells, including lymphoid and myeloid cells, can develop into phenotypically
distinct'subpopulations' with different functions. However, evidence indicates that some of …

Allergic disorders, such as anaphylaxis, hay fever, eczema and asthma, now afflict roughly
25% of people in the developed world. In allergic subjects, persistent or repetitive exposure …

Mast cells can promote inflammation and other tissue changes in IgE-associated allergic
disorders, as well as in certain innate and adaptive immune responses that are thought to be …

Mast cells are widely distributed in tissues, particularly near surfaces exposed to the
environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE …

Psoriasis pathogenesis is closely associated with disease‐inducing Th1 and Th17 cells. Yet,
several studies suggest that aberrant keratinocyte or endothelial cell signalling significantly …

Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice
suggest key roles for mast cells in certain antibody-and T cell-mediated autoimmune …

Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary dysfunctional disease,
characterized by progressive vascular remodeling. Inflammation is an increasingly …

The human gingiva, characterized by its outstanding scarless wound healing properties, is a
unique tissue and a pivotal component of the periodontal apparatus, investing and …

Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but
also play a fundamental role in innate and adaptive immune responses to microbial …