Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …

Fifteen years ago, the drive to study retroviruses was rooted principally in the traditional goal
of using animal models to understand human cancer. The historical importance of …

The possible use of pig organs and tissues as xenografts in humans is actively being
considered in biomedical research. We therefore examined whether pig endogenous …

ABSTRACT A new human endogenous retrovirus (HERV) family, termed HERV-W, was
recently described (J.-L. Blond, F. Besème, L. Duret, O. Bouton, F. Bedin, H. Perron, B …

Extracellular vesicles (EVs) have potential in disease treatment since they can be loaded
with therapeutic molecules and engineered for retention by specific tissues. However …

In the late 1970s, it was predicted that gene therapy would be applied to humans within a
decade. However, despite some success, gene therapy has still not become a routine …

The efficient delivery of therapeutic genes and appropriate gene expression are the crucial
issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which …

We have generated a human 293-derived retroviral packaging cell line (293GPG) capable
of producing high titers of recombinant Moloney murine leukemia virus particles that have …

Generating lentiviral vectors pseudotyped with different viral glycoproteins (GPs) may
modulate the physicochemical properties of the vectors, their interaction with the host …

Recent interest in the use of porcine organs, tissues, and cells for xenotransplantation to
humans has highlighted the need to characterize the properties of pig endogenous …