Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities
of self-renewal, differentiation, and tumorigenicity when transplanted into an animal host. A …

Lack of sensitive single-cell analysis tools has limited the characterization of metabolic
activity in cancer stem cells. By hyperspectral-stimulated Raman scattering imaging of single …

Malignant ascites presents a considerable clinical challenge to the management of ovarian
cancer, but also provides a wealth of opportunities for translational research. The …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Many modalities of cancer therapy induce mechanisms of treatment resistance and escape
pathways during chronic treatments, including photodynamic therapy (PDT). It is …

Chemoresistance to platinum therapy is a major obstacle that needs to be overcome in the
treatment of ovarian cancer patients. The high rates and patterns of therapeutic failure seen …

Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer
heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant …

Therapy-induced neuroendocrine prostate cancer (t-NEPC) is a highly aggressive subtype
of prostate cancer with poor patient survival. Emerging evidence indicates that t-NEPC can …

Seventy-five percent of patients with epithelial ovarian cancer present with advanced-stage
disease that is extensively disseminated intraperitoneally and prognosticates the poorest …