Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

RhoA GTPase plays a variety of functions in regulation of cytoskeletal proteins, cellular
morphology, and migration along with various proliferation and transcriptional activity in …

Radiotherapy remains the mainstay for treatment of various types of human cancer;
however, the clinical efficacy is often limited by radioresistance, in which the underlying …

Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular
processes, including cell migration, adhesion, and proliferation, by regulating the functions …

Background The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully
elucidated. Ras homology family member A (RhoA) plays an important role in regulating cell …

While Rho-signalling controlling vascular contraction is a canonical mechanism, with the
modern approaches used in research, we are advancing our understanding and details into …

Background: Pulmonary artery endothelial cell (PAEC) inflammation is a critical event in the
development of pulmonary arterial hypertension (PAH). However, the pathogenesis of PAEC …

Significance: Skeletal muscle is a crucial tissue to whole-body locomotion and metabolic
health. Reactive oxygen species (ROS) have emerged as intracellular messengers …

Sorafenib is the first FDA-approved first-line targeted drug for advanced HCC. However,
resistance to sorafenib is frequently observed in clinical practice, and the molecular …

Inflammation plays a crucial role in tumorigenesis, primarily mediated by NF-κB. RhoA
GTPases are instrumental in regulating the activation of NF-κB. Specifically, the …