Reactive species play an important role in physiological functions. Overproduction of
reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the …

Mitochondria is one of the main source of oxidative stress (ROS), as it utilizes the oxygen for
the energy production. ROS and RNS are normally generated by tightly regulated enzymes …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS, eg nitric oxide, NO) are
well recognised for playing a dual role as both deleterious and beneficial species. ROS and …

Oxygen-free radicals, more generally known as reactive oxygen species (ROS) along with
reactive nitrogen species (RNS) are well recognised for playing a dual role as both …

The development of cancer in humans and animals is a multistep process. The complex
series of cellular and molecular changes participating in cancer development are mediated …

A major development of carcinogenesis research in the past 20 years has been the
discovery of significant levels of DNA damage arising from endogenous cellular sources …

A wide array of chronic inflammatory conditions predispose susceptible cells to neoplastic
transformation. In general, the longer the inflammation persists, the higher the risk of cancer …

Faithful maintenance of the genome is crucial to the individual and to species. DNA damage
arises from both endogenous sources such as water and oxygen and exogenous sources …

Malondialdehyde (MDA) is an endogenous genotoxic product of enzymatic and oxygen
radical-induced lipid peroxidation whose adducts are known to exist in DNA isolated from …

Search for the formation of oxidatively base damage in cellular DNA has been a matter of
debate for more than 40years due to the lack of accurate methods for the measurement of …