Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine

KC Nicolaou, S Rigol - Natural product reports, 2020 - pubs.rsc.org
Covering: 1970 to 2020 By definition total synthesis is the art and science of making the
molecules of living Nature in the laboratory, and by extension, their analogues. Although …

Stereoselective semi‐hydrogenations of alkynes by first‐row (3d) transition metal catalysts

BJ Gregori, MOWS Schmotz… - …, 2022 - Wiley Online Library
The chemo‐and stereoselective semi‐hydrogenation of alkynes to alkenes is a fundamental
transformation in synthetic chemistry, for which the use of precious 4d or 5d metal catalysts …

Recent advances in asymmetric total synthesis of prostaglandins

H Peng, FE Chen - Organic & biomolecular chemistry, 2017 - pubs.rsc.org
Prostaglandins (PGs) are a series of hormone-like chemical messengers and play a critical
role in regulating physiological activity. The diversified therapeutic activities and complex …

Recent advancements in the use of Bobbitt's salt and 4-acetamidoTEMPO

JM Bray, SM Stephens, SM Weierbach… - Chemical …, 2023 - pubs.rsc.org
Recent advances in synthetic methodologies for selective, oxidative transformations using
Bobbitt's salt (4-acetamido-2, 2, 6, 6-tetramethyl-1-oxopiperidinium tetrafluoroborate, 1) and …

Intercepted Meyer–Schuster rearrangements in organic synthesis

D Roy, P Tharra, B Baire - Asian Journal of Organic Chemistry, 2018 - Wiley Online Library
Abstract The Meyer–Schuster rearrangement of propargylic alcohols is a transformation in
organic synthesis known for almost a century. The products of this reaction—α, β‐enones …

A concise and scalable chemoenzymatic synthesis of prostaglandins

Y Yin, J Wang, J Li - Nature Communications, 2024 - nature.com
Prostaglandins have garnered significant attention from synthetic chemists due to their
exceptional biological activities. In this report, we present a concise chemoenzymatic …

A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF 2α, fluprostenol, and travoprost guided by biocatalytic …

K Zhu, M Jiang, B Ye, GT Zhang, W Li, P Tang… - Chemical …, 2021 - pubs.rsc.org
Development of efficient and stereoselective synthesis of prostaglandins (PGs) is of utmost
importance, owing to their valuable medicinal applications and unique chemical structures …

Total synthesis endeavors and their contributions to science and society: A personal account

KC Nicolaou, S Rigol, R Yu - CCS Chemistry, 2019 - chinesechemsoc.org
The advent of organic synthesis in the 19th century, serendipitous as it was, set in motion a
revolution in science that continues to evolve into increasing levels of sophistication and to …

Concise Syntheses of Δ12-Prostaglandin J Natural Products via Stereoretentive Metathesis

J Li, TS Ahmed, C Xu, BM Stoltz… - Journal of the American …, 2018 - ACS Publications
Δ12-Prostaglandin J family is recently discovered and has potent anticancer activity.
Concise syntheses of four Δ12-prostaglandin J natural products (7–8 steps in the longest …

Reoptimization of the Organocatalyzed Double Aldol Domino Process to a Key Enal Intermediate and Its Application to the Total Synthesis of Δ12‐Prostaglandin J3

A Pelšs, N Gandhamsetty, JR Smith… - … A European Journal, 2018 - Wiley Online Library
Re‐investigation of the l‐proline catalyzed double aldol cascade dimerization of
succinaldehyde for the synthesis of a key bicyclic enal intermediate, pertinent in the field of …