Secretion of gonadotropic hormones from pituitary gonadotropes in response to
gonadotropin-releasing hormone (GnRH) is essential for regulation of reproductive …

The secretion of GH from pituitary somatotrophs is mainly regulated by alterations in the
levels of intracellular free Ca 2+ concentrations ([Ca 2+] i) that depend on the influx of Ca 2+ …

THE positive inotropic effect of the sympathetic nervous system on the heart is partly
mediated by an increase in the voltage-gated Ca2+ current (I ca) This increase is generally …

NATRIURETIC peptides inhibit the release and action of many hormones through cyclic
guanosine monophosphate (cGMP) 1, 2, but the mechanism of cGMP action is unclear3. In …

THE neuropeptide somatostatin inhibits secretion from electrically excitable cells in the
pituitary, pancreas, gut and brain1. In mammalian pituitary tumour cells somatostatin inhibits …

Modulation of the activity of potassium and other ion channels is an essential feature of
nervous system function. The open probability of a large conductance Ca2+-activated K+ …

Large conductance voltage-and calcium-activated potassium (BKCa) channels are
important signaling molecules that are regulated by multiple protein kinases and protein …

Adrenal corticosteroids have well known and profound effects on neurons and
neuroendocrine cells, but the underlying cellular mechanisms are poorly understood. The …

Large-conductance calcium-and voltage-activated potassium (BK) channels play a
fundamental role in the signaling pathways regulating mouse anterior pituitary corticotrope …

Most electrical and ionic properties of anterior pituitary cells are common to all pituitary cell
types; only gonadotropes exhibit a few cell specific features. Under basal conditions, the …