Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Rationale: Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and
features of plaque instability, in part, through lipid-mediated oxidative DNA damage and …

The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

A decline in capillary density and blood flow with age is a major cause of mortality and
morbidity. Understanding why this occurs is key to future gains in human health. NAD …

Vascular calcification (VC) is regarded as an important pathological change lacking effective
treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin …

Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Cellular senescence is a complex stress response that permanently arrests the proliferation
of cells at risk for oncogenic transformation. However, senescent cells can also drive …

Sirtuins are NAD+-dependent deacetylase and deacylase enzymes that control important
cellular processes, including DNA damage repair, cellular metabolism, mitochondrial …