The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

The AAA+-type ATPase p97 governs an ever-expanding number of cellular processes
reaching from degradation of damaged proteins and organelles to key signaling events and …

p97 is a hexameric AAA+ adenosine triphosphatase (ATPase) that is an attractive target for
cancer drug development. We report cryo–electron microscopy (cryo-EM) structures for …

p97/VCP (known as Cdc48 in S. cerevisiae or TER94 in Drosophila) is one of the most
abundant cytosolic ATPases. It is highly conserved from archaebacteria to eukaryotes. In …

Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …

The AAA-ATPase p97 plays vital roles in mechanisms of protein homeostasis, including
ubiquitin–proteasome system (UPS) mediated protein degradation, endoplasmic reticulum …

Despite the recent successes of targeted cancer immuno-therapies, drug resistance and
disease relapse remain a huge burden in cancer patient treatment. This has fueled renewed …

Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …

The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis
and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin …

The AAA+ ATPase, p97, also referred to as VCP, plays an essential role in cellular
homeostasis by regulating endoplasmic reticulum-associated degradation (ERAD) …