Therapeutic efficacy of 6-gingerol and 6-shogaol in promoting browning of white adipocytes vis-à-vis enhanced thermogenesis portrayed in high fat milieu

SJP Sampath, S Birineni, S Perugu, N Kotikalapudi… - Food Bioscience, 2021 - Elsevier
Ginger is a culinary spice, well documented for its inherent potent health beneficial effects,
with Gingerols and Shogaols contributing as major bioactive constituents (23–25% and 18 …

Treatment of 'diabesity': beyond pharmacotherapy

H Singh, V Venkatesan - Current Drug Targets, 2018 - ingentaconnect.com
Obesity is a prominent risk factor for type 2 diabetes. Management of type 2 diabetes
requires weight management in addition to glycemic parameters. For obese type 2 diabetes …

Metabolic syndrome predisposes to osteoarthritis: lessons from model system

SSJ Pragasam, V Venkatesan - Cartilage, 2021 - journals.sagepub.com
Objective The present study aims to assess for temporal changes in tibial subchondral bone
and cartilage in WNIN/Gr-Ob rats (portraying obesity, insulin resistance, dyslipidemia …

Emerging therapeutic targets for metabolic syndrome: lessons from animal models

H Singh, SJ Pragasam… - Endocrine, Metabolic & …, 2019 - ingentaconnect.com
Background: Metabolic syndrome is a cluster of medical conditions that synergistically
increase the risk of heart diseases and diabetes. The current treatment strategy for metabolic …

Immunolocalization of Nestin-Positive Cells in Islets of WNIN-Obese Rats: Implication in Obesity and Acute Pancreatitis

H Singh, V Venkatesan - Cellular and Molecular Medicine Research, 2023 - thecmmr.org
Background: WNIN-obese rats are novel animal model to study metabolic syndrome. The
islets of WNIN-obese rats have increased pancreatic inflammation and stress. The role of …