The polypharmacological effects of cannabidiol

J Castillo-Arellano, A Canseco-Alba, SJ Cutler, F León - Molecules, 2023 - mdpi.com
Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753).
This naturally occurring secondary metabolite does not induce intoxication or exhibit the …

Role of cannabidiol in the therapeutic intervention for substance use disorders

F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2021 - frontiersin.org
Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …

Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-HT1A and TRPV1 receptor mechanisms

E Galaj, GH Bi, HJ Yang, ZX Xi - Neuropharmacology, 2020 - Elsevier
Cocaine abuse continues to be a serious health problem worldwide. Despite intense
research there is currently no FDA-approved medication to treat cocaine use disorder. The …

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms

GP Silote, A Sartim, A Sales, A Eskelund… - Journal of chemical …, 2019 - Elsevier
Significant limitations with the currently available antidepressant treatment strategies have
inspired research on finding new and more efficient drugs to treat depression. Cannabidiol …

PLGA nanoparticles for the intraperitoneal administration of CBD in the treatment of ovarian cancer: In Vitro and In Ovo assessment

AI Fraguas-Sánchez, AI Torres-Suárez, M Cohen… - Pharmaceutics, 2020 - mdpi.com
The intraperitoneal administration of chemotherapeutics has emerged as a potential route in
ovarian cancer treatment. Nanoparticles as carriers for these agents could be interesting by …

Cannabidiol in the context of substance use disorder treatment: A systematic review

V Paulus, J Billieux, A Benyamina, L Karila - Addictive behaviors, 2022 - Elsevier
Introduction Cannabidiol (CBD) is a phytocannabinoid found in the Cannabis plant. CBD
has received significant medical attention in relation to its anticonvulsant, anxiolytic, and …

Cannabidiol as a novel candidate alcohol use disorder pharmacotherapy: a systematic review

J Turna, SK Syan, BN Frey, B Rush… - Alcoholism: Clinical …, 2019 - Wiley Online Library
There is substantial interest in the therapeutic potential of cannabidiol (CBD), a
nonpsychoactive cannabinoid found in plants of the genus Cannabis. The goal of the current …

Cannabidiol treatment might promote resilience to cocaine and methamphetamine use disorders: a review of possible mechanisms

C Calpe-López, MP García-Pardo, MA Aguilar - Molecules, 2019 - mdpi.com
Currently, there are no approved pharmacotherapies for addiction to cocaine and other
psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a …

Possible receptor mechanisms underlying cannabidiol effects on addictive-like behaviors in experimental animals

E Galaj, ZX Xi - International Journal of Molecular Sciences, 2020 - mdpi.com
Substance use disorder (SUD) is a serious public health problem worldwide for which
available treatments show limited effectiveness. Since the legalization of cannabis and the …

Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits

SK Jha, VK Nelson, PR Suryadevara, SP Panda… - Ageing Research …, 2024 - Elsevier
Neurodegenerative disorders (NDs) such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis are severe and …