Life on earth is shaped by the 24-h rotation of our planet around its axes. To adapt behavior
and physiology to the concurring profound but highly predictable changes, endogenous …

Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity
worldwide. Strategies to improve their treatment and prevention are global priorities and …

OBJECTIVE Recent experimental studies have shown that dipeptidyl peptidase 4 (DPP-4)
inhibitors have antiatherosclerotic benefits in glucagon-like peptide 1–dependent and …

Peroxisome proliferator‐activated receptor Gamma (PPARγ), a ligand‐activated
transcription factor, has a role in various cellular functions as well as glucose homeostasis …

Although elevated levels of serum low-density lipoprotein cholesterol (LDL-C) are the major
cause of onset of the disease, as established by a large number of superb epidemiological …

Atherosclerosis (AS) is a chronic inflammatory disease involving blood vessels.
Inflammation affects different cells and increases the expression of adhesion molecules …

The development of emphysema in humans and mice exposed to cigarette smoke is
promoted by activation of an adaptive immune response. Lung myeloid dendritic cells …

Macrophages play a crucial role during the pathogenesis of multiple sclerosis (MS), a
neuroinflammatory autoimmune disorder of the central nervous system. Important regulators …

Medial arterial calcification associated with hyperphosphatemia is a main cause of
cardiovascular mortality in patients with chronic kidney disease (CKD), but the mechanisms …

Peroxisome proliferator-activated receptor γ (PPAR-γ) is a key regulator of fatty acid
metabolism, promoting its storage in adipose tissue and reducing circulating concentrations …