Porphyromonas gingivalis, Treponema denticola, andTannerella forsythia: the 'red complex', a prototype polybacterial pathogenic consortium in periodontitis.

SC Holt, JL Ebersole - Periodontology 2000, 2005 - search.ebscohost.com
Disrobes the characterization of the periodontal diseases as multifactorial infections elicited
by a complex of bacterial species that interact with host tissues and cells. Cause of cells to …

Role of bacterial proteinases in matrix destruction and modulation of host responses.

JAN Potempa, A Banbula, JIM Travis - Periodontology 2000, 2000 - search.ebscohost.com
Discusses the role of bacterial proteinases in matrix destruction and modulation of host
responses. Evasion of host defense mechanisms; Mechanism of gingipain inference with …

Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes

J Potempa, A Sroka, T Imamura… - Current Protein and …, 2003 - ingentaconnect.com
Gingipains, extracellular cysteine proteinases of Porphyromonas gingivalis, constitute the
major virulence factor of this periodontopathogenic bacterium. They are the product of three …

Subgingival colonization by Porphyromonas gingivalis

RJ Lamont, HF Jenkinson - Oral Microbiology and Immunology …, 2000 - Wiley Online Library
Porphyromonas gingivalis, a gram‐negative anaerobe, is a major causative agent in the
initiation and progression of severe forms of periodontal disease. In order to cause …

Microbial and fungal protease inhibitors—current and potential applications

J Sabotič, J Kos - Applied microbiology and biotechnology, 2012 - Springer
Proteolytic enzymes play essential metabolic and regulatory functions in many biological
processes and also offer a wide range of biotechnological applications. Because of their …

Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8

CA Abbott, DMT Yu, E Woollatt… - European journal of …, 2000 - Wiley Online Library
Dipeptidyl peptidase (DPP) IV has roles in T‐cell costimulation, chemokine biology, type‐II
diabetes and tumor biology. Fibroblast activation protein (FAP) has been implicated in tumor …

Bacterial protease inhibitors

CT Supuran, A Scozzafava… - Medicinal Research …, 2002 - Wiley Online Library
Abstract Serine‐, cysteine‐, and metalloproteases are widely spread in many pathogenic
bacteria, where they play critical functions related to colonization and evasion of host …

Porphyromonas gingivalis Proteinases as Virulence Determinants in Progression of Periodontal Diseases

T Kadowaki, K Nakayama, K Okamoto… - The journal of …, 2000 - academic.oup.com
Porphyromonas gingivalis, one of the major causative agents of periodontal diseases,
produces large amounts of arginine-and lysine-specific cysteine proteinases in cell …

Bacterial proteases: current therapeutic use and future prospects for the development of new antibiotics

CT Supuran, A Scozzafava… - Expert Opinion on …, 2001 - Taylor & Francis
Proteases of the serine-, cysteine-and metallo-type are widely spread in many pathogenic
bacteria, where they play critical functions related to colonisation and evasion of host …

Targeting prolyl tripeptidyl peptidase from with the bioactive compounds from

AK Ramalingam, SGA Selvi, VP Jayaseelan - Asian Biomedicine, 2019 - sciendo.com
Background: Complications in periodontitis and other systemic infections related to
Porphyromonas gingivalis poses a serious impediment in the treatment process. This leads …