Cancer-induced systemic pre-conditioning of distant organs: Building a niche for metastatic cells

N Rabas, RMM Ferreira, S Di Blasio… - Nature Reviews Cancer, 2024 - nature.com
From their early genesis, tumour cells integrate with the surrounding normal cells to form an
abnormal structure that is tightly integrated with the host organism via blood and lymphatic …

Protein-based delivery systems for RNA delivery

H Zhu, H Luo, R Chang, Y Yang, D Liu, Y Ji… - Journal of Controlled …, 2023 - Elsevier
RNA-based therapeutics have emerged as promising approaches to modulate gene
expression and generate therapeutic proteins or antigens capable of inducing immune …

miRNA and leptin signaling in metabolic diseases and at extreme environments

S Mondal, R Rathor, SN Singh… - Pharmacology …, 2024 - Wiley Online Library
The burden of growing concern about the dysregulation of metabolic processes arises due
to complex interplay between environment and nutrition that has great impact on genetics …

Hypoxia preconditioning of adipose stem cell-derived exosomes loaded in gelatin methacryloyl (GelMA) promote type H angiogenesis and osteoporotic fracture repair

X Li, S Fang, S Wang, Y Xie, Y Xia, P Wang… - Journal of …, 2024 - Springer
The challenges posed by delayed atrophic healing and nonunion stand as formidable
obstacles in osteoporotic fracture treatment. The processes of type H angiogenesis and …

Unravelling the Role of Cancer Cell-Derived Extracellular Vesicles in Muscle Atrophy, Lipolysis, and Cancer-Associated Cachexia

AL Marzan, SV Chitti - Cells, 2023 - mdpi.com
Cancer-associated cachexia is a metabolic syndrome that causes significant reduction in
whole-body weight due to excessive loss of muscle mass accompanied by loss of fat mass …

IL36G-producing neutrophil-like monocytes promote cachexia in cancer

Y Hayashi, Y Kamimura-Aoyagi, S Nishikawa… - Nature …, 2024 - nature.com
Most patients with advanced cancer develop cachexia, a multifactorial syndrome
characterized by progressive skeletal muscle wasting. Despite its catastrophic impact on …

Systemic metabolic crosstalk as driver of cancer cachexia

E Wyart, G Carrà, E Angelino, F Penna… - Trends in Endocrinology …, 2025 - cell.com
Cachexia is a complex metabolic disorder characterized by negative energy balance due to
increased consumption and lowered intake, leading to progressive tissue wasting and …

[HTML][HTML] The Role of Non-Coding RNAs in Regulating Cachexia Muscle Atrophy

G Chen, J Zou, Q He, S Xia, Q Xiao, R Du, S Zhou… - Cells, 2024 - mdpi.com
Cachexia is a late consequence of various diseases that is characterized by systemic
muscle loss, with or without fat loss, leading to significant mortality. Multiple signaling …

Mechanisms of cancer cachexia and targeted therapeutic strategies

L Li, ZQ Ling - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Tumor cachexia is a multifactorial syndrome characterized by systemic dysfunction,
including anorexia and severe weight loss that is resistant to standard nutritional …

Exercise promotes peripheral glycolysis in skeletal muscle through miR-204 induction via the HIF-1α pathway

SR Lee, KJ Jeong, M Mukae, J Lee, EJ Hong - Scientific Reports, 2025 - nature.com
The mechanisms underlying exercise-induced insulin sensitization are of great interest, as
exercise is a clinically critical intervention for diabetic patients. Some microRNAs (miRs) are …