The hippo pathway effector TAZ regulates ferroptosis in renal cell carcinoma
Despite recent advances, the poor outcomes in renal cell carcinoma (RCC) suggest novel
therapeutics are needed. Ferroptosis is a form of regulated cell death, which may have …
therapeutics are needed. Ferroptosis is a form of regulated cell death, which may have …
Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo pathways: The therapeutic implications
Ferroptosis is a novel form of iron-dependent cell death characterized by lipid peroxidation.
While the importance and disease relevance of ferroptosis is gaining recognition, much …
While the importance and disease relevance of ferroptosis is gaining recognition, much …
A TAZ–ANGPTL4–NOX2 Axis regulates ferroptotic cell death and chemoresistance in epithelial ovarian cancer
Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical
outcomes remain poor, necessitating novel therapeutic approaches. To investigate …
outcomes remain poor, necessitating novel therapeutic approaches. To investigate …
Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism
Ferroptosis is a specialized iron-dependent cell death that is associated with lethal lipid
peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been …
peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been …
MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis
Critical to the bacterial stringent response is the rapid relocation of resources from
proliferation toward stress survival through the respective accumulation and degradation of …
proliferation toward stress survival through the respective accumulation and degradation of …
Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer
MB Siegel, X He, KA Hoadley, A Hoyle… - The Journal of …, 2018 - Am Soc Clin Investig
Breast cancer metastasis remains a clinical challenge, even within a single patient across
multiple sites of the disease. Genome-wide comparisons of both the DNA and gene …
multiple sites of the disease. Genome-wide comparisons of both the DNA and gene …
The intersection of DNA damage response and ferroptosis—a rationale for combination therapeutics
Ferroptosis is a novel form of iron-dependent cell death characterized by lipid peroxidation.
While the importance and disease relevance of ferroptosis are gaining recognition, much …
While the importance and disease relevance of ferroptosis are gaining recognition, much …
Protoplast Isolation and Shoot Regeneration from Protoplast-Derived Callus of Petunia hybrida Cv. Mirage Rose
Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …
regeneration from protoplasts remains challenging. In this study, we investigated the factors …
RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence
The molecular and genetic basis of tumor recurrence is complex and poorly understood.
RIPK3 is a key effector in programmed necrotic cell death and, therefore, its expression is …
RIPK3 is a key effector in programmed necrotic cell death and, therefore, its expression is …
Metabolomic effects of androgen deprivation therapy treatment for prostate cancer
Androgen deprivation therapy (ADT) is the main treatment strategy for men with metastatic
prostate cancer (PC). However, ADT is associated with various metabolic disturbances …
prostate cancer (PC). However, ADT is associated with various metabolic disturbances …