The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

Somatic cells accumulate genomic alterations with age; however, our understanding of
mitochondrial DNA (mtDNA) mosaicism remains limited. Here we investigated the genomes …

Esophageal squamous cell carcinoma (ESCC) develops through a series of increasingly
abnormal precancerous lesions. Previous studies have revealed the striking differences …

Oncogenic PIK3CA mutations generate large clones in aging human esophagus. Here we
investigate the behavior of Pik3ca mutant clones in the normal esophageal epithelium of …

Aging epithelia are colonized by somatic mutations, which are subjected to selection
influenced by intrinsic and extrinsic factors. The lack of suitable culture systems has slowed …

Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …

The molecular basis of disease progression from UV-induced precancerous actinic keratosis
(AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially …

The prevalence and nature of somatic copy number alterations (CNAs) in breast epithelium
and their role in tumor initiation and evolution remain poorly understood. Using single-cell …

The term 'precancer'typically refers to an early stage of neoplastic development that is
distinguishable from normal tissue owing to molecular and phenotypic alterations, resulting …