Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Like other pathogens, parasitic helminths can rapidly evolve resistance to drug treatment.
Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is …

Background Aging leads to decreased skeletal muscle function in mammals and is
associated with a progressive loss of muscle mass, quality and strength. Age-related muscle …

The systematic bioanalytical characterization of the protein product of the DMD gene, which
is defective in the pediatric disorder Duchenne muscular dystrophy, led to the discovery of …

Since its first description in 1990, the dystrophin–glycoprotein complex has emerged as a
critical nexus for human muscular dystrophies arising from defects in a variety of distinct …

Complex mechanisms are required to form neuromuscular synapses, direct their
subsequent maturation, and maintain the synapse throughout life. Transcriptional and post …

An increasing body of evidence suggests that several membrane receptors–in addition to
activating distinct signalling cascades–also engage in substantial crosstalk with each other …

Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, activate
Trk receptor tyrosine kinases through receptor dimerization at the cell surface followed by …

Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is
key to improving the efficacy and sustainability of parasite control. Here, we use a genetic …